Guest Researcher

diego.rodriguez.hernandez@gu.se

EDUCTAION AND EXPERIENCE

2024-present: Guest Researcher

University of Gothenburg, Sweden

2022–2023: Postdoctoral Fellow

University of Bergen, Norway

2019-2022: Postdoctoral Fellow

University of Gothenburg, Sweden

2017–2019: Postdoctoral Fellow

São Paulo University (FCFRP-USP); Brazil

2012-2016: PhD student

Federal University of Viçosa, Brazil

RESEARCH INTERESTS

My current research focuses on synthetic organic, medicinal, and nucleotide chemistry, particularly the design and synthesis of bioactive molecules and nucleoside analogs. I am interested in developing chemically modified nucleotides such as Nucleotide Reversible Terminators (NRTs) and in studying enzyme inhibition mechanisms, including N-myristoyltransferase (NMT) inhibitors. My work integrates computational and experimental approaches to explore structure–activity relationships and support drug discovery innovation.

PUBLICATIONS

Sulfated Flavonoids from Phyllospadix (Zosteraceae) Taxa from Baja California, Mexico Diego Rodríguez-Hernández, Jose Miguel Sandoval-Gil, Kjersti Hasle Enerstvedt, Susana Villa Gonzalez, Alejandra Ferreira-Arrieta, Alexandros G. Asimakopoulos, and Monica Jordheim. ACS Omega. 2025, 10, 6079-6091.

Exploring Subsite Selectivity within Plasmodium vivax N-Myristoyltransferase Using Pyrazole-Derived Inhibitors Diego Rodríguez-Hernández, Michael K. Fenwick, Rachael Zigweid, Banumathi Sankaran, Peter J. Myler, Per Sunnerhagen, Alexis Kaushansky, Bart L. Staker, and Morten Grøtli. J. Med. Chem. 2024, 67, 7312-7329

Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts. Diego Rodríguez-Hernández, Kamalakannan Vijayan, Rachael Zigweid, Michael K. Fenwick, Banumathi Sankaran, Wanlapa Roobsoong, Jetsumon Sattabongkot, Elizabeth K. K. Glennon, Peter J. Myler, Per Sunnerhagen, Bart L. Staker, Alexis Kaushansky & Morten Grøtli. Nat. Commun. 2023, 14, 5408.

Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative Bacteria. Bourgard, C.; Rodríguez-Hernández, D.; Rudenko, A.; Rutgersson, C.; Palm, M.; Larsson, D.G.J.; Farewell, A.; Grøtli, M.; Sunnerhagen, P. Antibiotics. 2022, 11, 1115.

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. Laure NA Ries, Lakhansing Pardeshi, Zhiqiang Dong, Kaeling Tan, Jacob L Steenwyk, Ana Cristina Colabardini, Jaire A Ferreira Filho, Patricia A de Castro, Lilian P Silva, Nycolas W Preite, Fausto Almeida, Leandro J de Assis, Renato AC Dos Santos, Paul Bowyer, Michael Bromley, Rebecca A Owens, Sean Doyle, Marilene Demasi, Diego CR Hernandez, Luis Eduardo S Netto, Monica T Pupo, Antonis Rokas, Flavio V Loures, Koon H Wong, Gustavo H Goldman. PLOS Pathogens 2020, 16: e1008645.

Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp. Carla Menegatti, Vitor Bruno Lourenzon, Diego Rodríguez-Hernández, Weilan Gomes da Paixão Melo, Leonardo Luiz Gomes Ferreira, Adriano Defini Andricopulo, Fabio Santos do Nascimento, and Mônica Tallarico Pupo. J. Nat. Prod. 2020, 83, 610-616.

Antiureolytic Activity of Substituted 2,5-Diaminobenzoquinones. Amalyn Nain‐Perez, Luiz CA Barbosa, Diego Rodríguez‐Hernández, Yane CC Mota, Thamara F Silva, Teodorico C Ramalho, Luzia V Modolo. Chem. Biodivers. 2019, 16, e1900503.

Hederagenin amide derivatives as potential antiproliferative agents.Diego Rodríguez-Hernández, Luiz CA Barbosa, Antonio J Demuner, João Paulo Ataide Martins, René Csuk. Eur. J. Med. Chem. 2019, 168, 436.

Secondary metabolites as a survival strategy in plants of high mountain habitats.  Rodríguez-Hernández, D. Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas, Diego Rodríguez‐Hernández, 2019, 18, 444-458.

Actinobacteria associated with stingless bees biosynthesize bioactive polyketides against bacterial pathogens Diego Rodríguez-Hernández, Weilan GP Melo, Carla Menegatti, Vitor B Lourenzon, Fabio S do Nascimento, Mônica T Pupo. New J. Chem. 2019, 43, 10109-10117.

Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives. Diego Rodriguez-Hernandez, Luiz CA Barbosa, Antonio J Demuner, Amalyn Nain-Perez, Sebastião R Ferreira, Ricardo T Fujiwara, Raquel M de Almeida, Lucie Heller, Rene Csuk. Eur. J. Med. Chem. 2017, 140, 624.

Two new labdane diterpenoids from the foliar exudates of Blakiella bartsiifolia. Diego Rodriguez-Hernandez, Alberto Oliveros-Bastidas, Miguel E Alonso-Amelot, Maria Pia Calcagno-Pissarelli. Phytochem. Lett. 2017, 20, 269-273.

Natural Abenquines and Synthetic Analogues: Preliminary Exploration of their Cytotoxic Activity. Amalyn Nain-Perez, Luiz C.A. Barbosaa, Diego Rodríguez-Hernández, Annemarie E. Kramell, Lucie Heller, René Csuk. Bioorg. Med. Chem. Lett. 2017, 27, 1141-1144.

Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from Sapindus saponaria L. Diego Rodríguez-Hernández, Luiz CA Barbosa, Antonio J Demuner, Raquel M de Almeida, Ricardo T Fujiwara, Sebastiao R Ferreira. Eur. J. Med. Chem. 2016, 124, 153.

Cyanolipids from Sapindus saponaria L. seeds oil. Diego Rodríguez-Hernández, Antonio J Demuner, Ricardo M Montanari, Luiz CA Barbosa, Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas, 2016, 15, 364-372. 

Novel hederagenin–triazolyl derivatives as potential anti-cancer agents. Diego Rodríguez-Hernández, Antonio J Demuner, Luiz CA Barbosa, Lucie Heller, René Csuk. Eur. J. Med. Chem. 2016, 115, 257.

Hederagenin as a triterpene template for the development of new antitumor compounds. Diego Rodríguez-Hernández, Antonio J Demuner, Luiz CA Barbosa, René Csuk, Lucie Heller. Csuk. Eur. J. Med. Chem. 2015, 105, 57.

Diterpene Foliar Exudates of Blakiella bartsiifolia and Phytotoxicity of Clerodanes. Diego Rodriguez-Hernandez, Alberto Oliveros-Bastidas, Miguel E Alonso-Amelot, Maria Pia Calcagno-Pissarelli. Nat. Prod. Commun. 2014, 10, 1407-1412.

Estandarización de un bioensayo para la búsqueda de compuestos fitotóxicos en extractos vegetales. Alberto de J Oliveros-Bastidas, Diego C Rodríguez-Hernández, María Pía Calcagno-Pissarelli. CIENCIA 2011, 19, 187-202.

Foliar exudates of Blakiella bartsiifolia (S.F. Blake) Cuatrec. (Asteraceae, Astereae). A Preliminary study of the Chemical Composition. Maria Pia Calcagno-Pissarelli, Miguel Alonso-Amelot, Reynaldo Mora, Diego Rodríguez, Jorge Luis Ávila Núñez. Avances en Química, 2010, 5, 161-166.