Postdoctoral Fellow

marcelo.fiori.marchiori@gu.se

EDUCATION AND EXPERIENCE

• 2025-present: Postdoctoral Work

University of Gothenburg, Sweden

• 2018-2024: Ph.D in Sciences

University of São Paulo – School of Pharmaceutical Sciences of Ribeirão Preto, Brazil.

• 2016-2018: Master of Science (MS) degree

University of São Paulo – School of Pharmaceutical Sciences of Ribeirão Preto, Brazil.

• 01/2014-12/2014: Visiting Undergraduate Student

University of East Anglia, Norwich – United Kingdom.

• 2010-2015: B.S., Pharmacy-Biochemistry

University of São Paulo – School of Pharmaceutical Sciences of Ribeirão Preto, Brazil.

RESEARCH INTERESTS

My research interests lie in the interface of synthetic and medicinal chemistry, with a focus on the rational design, synthesis, and optimization of bioactive molecules. I have experience designing and synthesizing heterocycles, natural product-inspired molecules, glycoconjugates, and peptide-based compounds to address human diseases. Recently, I have been investigating novel allosteric scaffolds for PKL enzyme inhibition, combining synthesis, biological evaluation, and computational studies.

PUBLICATIONS

Synthesis and antifungal activity of polyalthic acid-1,2,3-triazole-arylsulfonamide derivatives. Marcelo Fiori Marchiori, Maria Angélica dos Santos Cunha Chellegatti, João Victor Silveira Camargo, Vânia Santos Braz, Sérgio R. Ambrósio, Jairo Kenupp Bastos, Guilherme Martins Silva, Niege Araçari Jacometti Cardoso Furtado and Vanessa Leiria Campo. Tetrahedron Lett. 2025, 171–172, 155814.

Rapid synthesis of novel pyrazino-pyrido-pyrimidinones derived from fumiquinazoline alkaloids. Marcelo Fiori Marchiori and Ivone Carvalho. J. Braz. Chem. Soc. 2025, 36, 1–13.

Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer’s disease and future perspectives. Natália Chermont dos Santos Moreira, Jéssica Ellen Barbosa de Freitas Lima, Marcelo Fiori Marchiori, Ivone Carvalho and Elza Tieme Sakamoto-Hojo. J. Alzheimers Dis. Rep. 2022, 6, 177–193.

Synthesis of MUC1-derived glycopeptide bearing a novel triazole STn analog. Marcelo F. Marchiori, Leandro O. Bortot, Ivone Carvalho and Vanessa L. Campo. Carbohydr. Res. 2020, 497, 108155.

Galactosyl and sialyl clusters: synthesis and evaluation against T. cruzi parasite. Andreza S. Figueredo, Peterson de Andrade, Thalita B. Riul, Marcelo F. Marchiori, Thais Canassa de Leo, Anna Karoline A. Fleuri, Sérgio Schenkman, Marcelo D. Baruffi and Ivone Carvalho. Pure Appl. Chem. 2019, 91, 1191–1207.

Multifaceted antibodies development against synthetic α-dystroglycan mucin glycopeptide as promising tools for dystroglycanopathies diagnostic. Thais Canassa-de Leo, Vanessa Leiria Campo, Lílian Cataldi Rodrigues, Marcelo Fiori Marchiori, Carlos Fuzo, Marcelo Macedo Brigido, Annamaria Sandomenico, Menotti Ruvo, Andrea Queiroz Maranhão and Marcelo Dias-Baruffi. Glycoconj. J. 2019, 37, 77–93.

Synthesis of novel triazole-derived glycopeptides as analogs of α-dystroglycan mucins. Marcelo Fiori Marchiori, Giulia Pompolo Iossi, Leandro Oliveira Bortot, Marcelo Dias-Baruffi and Vanessa Leiria Campo. Carbohydr. Res. 2019, 472, 23–32.

Insights into anti-trypanosomal agents based on synthetic glycoconjugates. Vanessa Leiria Campo, Marcelo Fiori Marchiori and Ivone Carvalho. Curr. Top. Med. Chem. 2018, 18, 382–396.

A synthetic MUC1 glycopeptide bearing βGalNAc-Thr as a Tn antigen isomer induces the production of antibodies against tumor cells. Vanessa Leiria Campo, Thalita B. Riul, Leandro Oliveira Bortot, Maristela B. Martins-Teixeira, Marcelo Fiori Marchiori, Emanuela Iaccarino, Menotti Ruvo, Marcelo Dias-Baruffi and Ivone Carvalho. ChemBioChem 2017, 18, 527–538.

Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion. Marcelo Fiori Marchiori, Thalita B. Riul, Leandro Oliveira Bortot, Peterson de Andrade, Getúlio G. Junqueira, Giuseppina Foca, Nunzianna Doti, Menotti Ruvo, Marcelo Dias-Baruffi, Ivone Carvalho and Vanessa Leiria Campo. Bioorg. Med. Chem. 2017, 25, 6049–6059.

Synthetic glycoconjugates inhibitors of tumor-related galectin-3: an update. Vanessa Leiria Campo, Marcelo Fiori Marchiori, Lílian Cataldi Rodrigues and Marcelo Dias-Baruffi. Glycoconj. J. 2016, 33, 856.

Synthetic 1,2,3-triazole-linked glycoconjugates bind with high affinity to human galectin-3. Marcelo Fiori Marchiori, Dênio Emanuel Pires Souto, Leandro Oliveira Bortot, João Francisco Pereira, Lauro Tatsuo Kubota, Richard D. Cummings, Marcelo Dias-Baruffi, Ivone Carvalho and Vanessa Leiria Campo. Bioorg. Med. Chem. 2015, 23, 3414–3425.